Various findings in prostate tissue indicate raised risk of later prostate cancer, and, of all these, the finding of high-grade prostatic intraepithelial neoplasia on repeated biopsy is most strongly associated. This Review discusses the morphologic spectrum and clinical importance of these proposed preneoplastic lesions and conditions of the prostate, especially high-grade prostatic intraepithelial neoplasia.
- Rodolfo Montironi
- Roberta Mazzucchelli
- Marina Scarpelli
