Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles.
- Rocio Gomez-Pastor
- Eileen T. Burchfiel
- Dennis J. Thiele
