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Showing 1–3 of 3 results
Advanced filters: Author: "Roger A. Nicoll" Clear advanced filters

  • In mediating fast synaptic communication in the brain, AMPA receptors require TARP auxiliary proteins. It seems that another distinct class of proteins also bind to AMPA receptors and regulate their function.

    • Alexander C. Jackson
    • Roger A. Nicoll
    News & Views
    Nature
    Volume: 458, P: 585-586

  • There is plenty of indirect evidence that the postsynaptic density (PSD)-95 protein is involved in the clustering and, perhaps, targeting of postsynaptic proteins. Direct evidence was lacking, but PSD-95 knockout mice have now arrived, and their properties support a clustering function. However, knocking out PSD-95 also disrupts synaptic plasticity, and this could mean that PSD-95 acts as a kind of scaffold protein.

    • Robert C. Malenka
    • Roger A. Nicoll
    News & Views
    Nature
    Volume: 396, P: 414-415