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Showing 1–3 of 3 results
Advanced filters: Author: "Ronald C Petersen" Clear advanced filters

  • Ronald Petersen developed the concept of mild cognitive impairment (MCI) in the late 1990s. The concept has since been expanded to include several subtypes, with amnestic MCI being recognized as a risk state for Alzheimer's disease. This Viewpoint highlights the benefits of retaining the MCI classification, both from a research and from a clinical point of view.

    • Ronald C Petersen
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 60-61

  • Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in the brain, but in whom biomarkers of neurodegeneration are abnormal. Clinically normal and mildly impaired individuals with SNAP are at increased risk of poor clinical and cognitive outcomes. In this Perspectives article, Clifford Jack and colleagues describe the available data on SNAP and address topical controversies in the field.

    • Clifford R. Jack Jr
    • David S. Knopman
    • Stephanie J. B. Vos
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 117-124