Alterations in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), have been described in various neurodegenerative disorders, most notably Huntington disease. In this article, Zuccato and Cattaneo review the current knowledge about the involvement of BDNF in these diseases and critically assess whether BDNF treatment would be a beneficial and feasible therapeutic approach in the clinic.
- Chiara Zuccato
- Elena Cattaneo
