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Showing 1–7 of 7 results
Advanced filters: Author: "Rui Costa" Clear advanced filters
  • Initial dopamine self-stimulations reinforced not only the stimulation-producing target action, but also actions similar to the target action and actions that occurred a few seconds before stimulation, and repeated pairings led to a gradual refinement of the behavioural repertoire to home in on the target actions.

    • Jonathan C. Y. Tang
    • Vitor Paixao
    • Rui M. Costa
    ResearchOpen Access
    Nature
    Volume: 626, P: 583-592
  • Behavioral feedback is critical for learning, but it is often not available. Here, the authors introduce a deep learning model in which the cerebellum provides the cerebrum with feedback predictions, thereby facilitating learning, reducing dysmetria, and making several experimental predictions.

    • Ellen Boven
    • Joseph Pemberton
    • Rui Ponte Costa
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18
  • The striatum is required for evoking contraversive movements from each brain hemisphere, but it is unclear how. Here, Tecuapetla et al.use optogenetics to inhibit direct and indirect downstream striatal projection pathways, and show that activity in both pathways is necessary for contraversive movements.

    • Fatuel Tecuapetla
    • Sara Matias
    • Rui M. Costa
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10
  • The authors trained mice to perform rapid action sequences while recording from neurons in the direct and indirect basal ganglia pathways. In addition to neurons whose activity reflected the start or stop of a sequence, they identified neurons that displayed sustained activity or inhibition throughout an entire action sequence.

    • Xin Jin
    • Fatuel Tecuapetla
    • Rui M Costa
    Research
    Nature Neuroscience
    Volume: 17, P: 423-430
  • The function of brain oscillations remains unclear, although a role in controlling the flow of signals among anatomically connected networks has been proposed. In this Opinion article, Akam and Kullmann discuss how network oscillations might convey multiplexed information that enables a flexible reconfiguration of effective connectivity among brain areas.

    • Thomas Akam
    • Dimitri M. Kullmann
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 111-122