Search

The relationships between the physical parameters of β–cyclodextrin-based nanoparticles (CDNPs), the behavior of α-mangostin release, and the anticancer efficacy were revealed in this study. It was found that the lifetime of complex (τ₂) in slow-release mode was linearly dependent on the nanoparticle density and showed a relationship with anticancer efficacy. We assumed that MGS released from CDNPs would accumulate in the tumor region if the optimal range of τ₂ was approximately 90 to 140 h. These results suggest τ₂ can be a critical quality attribute for designing our CDNPs.

Nanomorphology of sterically stabilized polypyrrole-palladium nanocomposite particles has been extensively characterized by transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS). High-resolution TEM studies revealed that non-spherical nanocomposite particles were produced with a Heywood diameter of ∼30 nm and also confirmed the existence of palladium nanocrystals with a diameter of 5.4 nm within the particles. SAXS studies on aqueous dispersions of the nanocomposite particles confirmed good colloidal stability and revealed 5.0 and 23 nm as average diameters for the Pd nanoparticles and the nanocomposite particles, respectively.

We examined drug release behavior and anticancer efficacy of cyclodextrin-based nanoparticles (CDNPs) containing alpha-mangostin (MGS) in three different type of CDs (α-, β-, and γ-CD). βCDNP containing MGS demonstrated the best anticancer efficacy, while no efficacy was observed for the other CDNPs. Our findings suggested the anticancer efficacy might depend on the drug retention capability in which the interior and surface CDs in the CDNPs relate to the slow and rapid release modes, respectively. We assume the drug retention capability of slow release mode is important for performing the anticancer efficacy.

In this study, we synthesized and characterized cyclodextrin-based nanoparticles (CDNPs) by polyaddition reactions using epichlorohydrin and three different type of CDs (α-, β-, and γ-CD). We found that cyclodextrin tended to cover surface of our nanoparticles; while epichlorohydrin network enlarged when weight ratio of epichlorohydrin/cyclodextrin increased. Our CDNPs demonstrated a very high loading ratio against α-mangostin (MGS), and getting close to 1:1 ratio.