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Showing 1–11 of 11 results
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  • Physical cues from the extracellular environment influence the lineage commitment of stem cells. Now, experiments on human mesenchymal stem cells cultured on photodegradable hydrogels show that the cells' fate can also be determined by past physical environments.

    • Jeroen Eyckmans
    • Christopher S. Chen
    News & Views
    Nature Materials
    Volume: 13, P: 542-543

  • Cell signalling that is normally biochemically regulated can now be stimulated, with reversible and external control, by attaching magnetic nanoparticles to a cell surface and applying a magnetic field.

    • Christopher S. Chen
    News & Views
    Nature Nanotechnology
    Volume: 3, P: 13-14

  • Parkinson disease (PD) affects up to 10 million people worldwide and is clinically diagnosed. Molecular phenotyping of patient samples might help to corroborate diagnosis, and a new study suggests that blood-based gene expression profiling might distinguish between patients with PD and those without. However, experience suggests that additional replication is needed.

    • Alice S. Chen-Plotkin
    News & Views
    Nature Reviews Neurology
    Volume: 14, P: 5-6

  • Ectopic foci in pulmonary veins can trigger episodes of atrial fibrillation, but how these foci arise remains unclear. Dr Mark Shen and colleagues review the role of the autonomous nervous system in the induction and maintenance of atrial arrhythmias, and discuss neural modulation as a treatment strategy for patients with atrial fibrillation.

    • Mark J. Shen
    • Eue-Keun Choi
    • Peng-Sheng Chen
    Reviews
    Nature Reviews Cardiology
    Volume: 9, P: 30-39

  • Daniel Batlle and colleagues present an approach to the diagnosis and evaluation of hyponatremia that is based on the often-underused concept of electrolyte-free water clearance. Illustrated by a case vignette, this approach is set in the context of emerging evidence supporting the utility of vasopressin receptor antagonists in the management of hyponatremia. The pharmacology, mechanism of action, and efficacy data for drugs of this class are reviewed.

    • Sheldon Chen
    • Nishant Jalandhara
    • Daniel Batlle
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 3, P: 82-95

  • TAR DNA-binding protein 43 (TDP-43) inclusions are the main histopathological feature of amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar degeneration (FTLD). In this article, Chen-Plotkinet al. examine the TDP-43 pathology found in these and other neurodegenerative diseases. They also argue for ALS and FTLD with TDP-43 inclusions to be considered as two ends of a continuum of disease that is characterized by TDP-43-mediated neurodegeneration.

    • Alice S. Chen-Plotkin
    • Virginia M.-Y. Lee
    • John Q. Trojanowski
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 211-220

  • This Timeline article provides a historical perspective on the generation of mouse models of breast cancer induced by ERBB2 (also known as HER2). What have these models taught us and how similar are they to human breast cancer?

    • Josie Ursini-Siegel
    • Babette Schade
    • William J. Muller
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 389-397