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Showing 1–4 of 4 results
Advanced filters: Author: "S. Grimmond" Clear advanced filters

  • Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

    • Andrew V. Biankin
    • Nicola Waddell
    • Sean M. Grimmond
    Research
    Nature
    Volume: 491, P: 399-405

  • Application of next-generation sequencing using the ABI SOLiD technology to mammalian transcriptome analysis enabled a survey of the content, the complexity and the developmental dynamics of the embryonic stem cell transcriptome in the mouse. Also in this issue, Mortazavi et al. report Illumina technology–based RNA-Seq analysis of the mouse transcriptome in three different tissues.

    • Nicole Cloonan
    • Alistair R R Forrest
    • Sean M Grimmond
    Research
    Nature Methods
    Volume: 5, P: 613-619

  • Piero Carninci and colleagues report that 6–30% of cap-selected mouse and human RNA transcripts initiate within repetitive elements. They conclude that retrotransposon transcription is far more widespread than first thought and has a major influence on the transcriptional output of mammalian genomes.

    • Geoffrey J Faulkner
    • Yasumasa Kimura
    • Piero Carninci
    Research
    Nature Genetics
    Volume: 41, P: 563-571