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Showing 1–8 of 8 results
Advanced filters: Author: "S. Lewis" Clear advanced filters

  • Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

    • Marco Todesco
    • Sureshkumar Balasubramanian
    • Detlef Weigel
    Research
    Nature
    Volume: 465, P: 632-636

  • Opiate drugs and opioid peptides differ in their effects on intracellular signalling, in which following ligand–receptor binding and internalization, opioids continue to signal from endosomes, whereas opiates activate receptors located at the Golgi.

    • Sian Lewis
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 19, P: 389

  • Elevated maternal IL-6 in the maternal circulation can enter the fetus via the maternal—placental—fetal route and alter neurodevelopmental processes, with potentially wide-ranging effects on brain function later in life.

    • Sian Lewis
    Research Highlights
    Nature Reviews Neuroscience
    Volume: 19, P: 321

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186

  • Meeting the world's energy needs requires the collective efforts of many different actors across a range of technologies and approaches. In this Feature, ten leading experts in energy research share their vision of the challenges their respective fields must address in the coming decades.

    • Robert C. Armstrong
    • Catherine Wolfram
    • M. V. Ramana
    Special Features
    Nature Energy
    Volume: 1, P: 1-8