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Showing 1–5 of 5 results
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  • Meroterpenoids are mixed terpenoid–polyketide natural products with a variety of biological activities. Now, a synthetic approach that combines biocatalytic oxidation with a range of other radical-based reactions enables the divergent synthesis of eight oxidized meroterpenoid natural products and one analogue.

    • Andrew Gomm
    • Adam Nelson
    News & Views
    Nature Chemistry
    Volume: 12, P: 109-111

  • A discovery approach termed activity-directed synthesis is described; it exploits arrays of reactions whose outcome is critically dependent on the conditions used, and prioritizes reactions that yield bioactive product mixtures. The discovery of both bioactive small molecules and associated synthetic routes thus occurs in parallel.

    • George Karageorgis
    • Stuart Warriner
    • Adam Nelson
    Research
    Nature Chemistry
    Volume: 6, P: 872-876

  • The discovery of new therapeutic targets and the personalization of treatments are two active areas of cancer research. New studies suggest that a 'co-clinical' approach may expedite both therapeutic target validation and risk stratification in patients with advanced prostate cancer.

    • Song Zhao
    • Peter S Nelson
    News & Views
    Nature Genetics
    Volume: 45, P: 718-720

  • Only a few types of natural amino-acid residue are used directly by enzymes to catalyse reactions. The incorporation of an unnatural residue into an enzyme shows how the catalytic repertoire of enzymes can be enlarged.

    • Adam Nelson
    News & Views
    Nature
    Volume: 570, P: 172-173

  • The discovery of bioactive small molecules is generally driven via iterative design–make–purify–test cycles. Progress has been made towards the automation and integration of adjacent stages within such discovery workflows, which can increase the efficiency and effectiveness of bioactive small-molecule discovery.

    • Shiao Chow
    • Samuel Liver
    • Adam Nelson
    Reviews
    Nature Reviews Chemistry
    Volume: 2, P: 174-183