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Showing 1–2 of 2 results
Advanced filters: Author: "S. Qi" Clear advanced filters

  • Non-coding RNA devices, such as CRISPR–Cas systems, riboswitches and RNA scaffolds, have emerged as a versatile class of genetic regulatory elements that are used in a broad range of synthetic biology applications. In this Review, Arkin and Qi discuss the design, engineering and application of synthetic non-coding RNA devices for microbial engineering.

    • Lei S. Qi
    • Adam P. Arkin
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 341-354

  • The CRISPR–Cas9 system is a powerful, sequence-specific tool that was initially developed for gene and genome editing. The recent adoption of nuclease-deactivated Cas9 (dCas9) has enabled expansion of the use of the system to multiplexed and inducible transcription regulation, genome-wide screens and cell fate engineering.

    • Antonia A. Dominguez
    • Wendell A. Lim
    • Lei S. Qi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 5-15