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Showing 1–3 of 3 results
Advanced filters: Author: "Salvatore Pece" Clear advanced filters

  • The p140Cap adaptor protein is a tumour suppressor associated with improved prognosis in breast cancer. Here, the authors identify a role for p140Cap in preventing the immunosuppressive and pro-tumour function of polymorphonuclear myeloid-derived suppressor cells via downmodulation of the β-Catenin/Tumor Initiating Cells/G-CSF axi

    • Vincenzo Salemme
    • Mauro Vedelago
    • Paola Defilippi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-22

  • Finding biomarkers for targeted therapy is a promising approach to treat cancer. Here, the authors show that in breast cancer preclinical models and patients, CDK12 promotes tumourigenesis but induces selective vulnerability to therapies that target folate one-carbon metabolism.

    • M. G. Filippone
    • D. Gaglio
    • S. Pece
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Numb functions as a tumour suppressor protein by regulating another tumour suppressor, p53. Numb binds and inhibits the activity of the ubiquitin ligase HDM2, and thereby promotes p53 stability and function. Low levels of Numb expression in breast tumours is associated with a poor prognosis.

    • Ivan N. Colaluca
    • Daniela Tosoni
    • Pier Paolo Di Fiore
    Research
    Nature
    Volume: 451, P: 76-80