The amyloid-β (Aβ) peptide accumulates in extracellular plaques that are linked to Alzheimer's disease, and recent evidence indicates that Aβ can also accumulate intraneuronally. LaFerla and colleagues review the production and regulation of intracellular Aβ and discuss its potential contribution to neuronal pathology.
- Frank M. LaFerla
- Kim N. Green
- Salvatore Oddo
