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Showing 1–5 of 5 results
Advanced filters: Author: "Sascha Martens" Clear advanced filters

  • Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.

    • Eleonora Turco
    • Adriana Savova
    • Sascha Martens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin–proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.

    • Sascha Martens
    • Andreas Bachmair
    News & Views
    Nature Cell Biology
    Volume: 17, P: 841-842

  • The Cvt pathway in yeast operates constitutively, but the mechanism by which non-cargo material is excluded from the vacuole is incompletely defined. Martens and colleagues show that cargo binding to the cargo receptor Atg19 exposes further Atg8 binding sites on the receptor, which draws the isolation membrane around the autophagic cargo and prevents inclusion of non-cargo material in autophagosomes.

    • Justyna Sawa-Makarska
    • Christine Abert
    • Sascha Martens
    Research
    Nature Cell Biology
    Volume: 16, P: 425-433

  • Although fusion proteins that function in different membrane-fusion events can be structurally diverse, their functional activities are often similar. Fusion proteins bring the two membranes into sufficiently close proximity and inject energy into the fusion process.

    • Sascha Martens
    • Harvey T. McMahon
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 543-556