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Showing 1–4 of 4 results
Advanced filters: Author: "Scott Powers" Clear advanced filters

  • Current cancer therapies exert selective pressures that drive the evolution of drug-resistant clones. In this Opinion article, the authors argue that induction of stable tumour reversion represents an alternative strategy that could reduce resistance and thus effectively and durably treat cancer.

    • Scott Powers
    • Robert E. Pollack
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 266-270

  • How many of the changes identified in human cancer by genome sequencing are meaningful? And how can we exploit these massive data sets to yield new therapeutic targets? This article outlines five approaches that aim to discover oncogenic drivers, tumour dependencies and, ultimately, new cancer therapies from cancer genome data.

    • Cheryl Eifert
    • R. Scott Powers
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 572-578

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906