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Showing 1–2 of 2 results
Advanced filters: Author: "Scott Stroup" Clear advanced filters

  • Schizophrenia is a highly heritable genetic disorder, however, identification of specific genetic risk variants has proven difficult because of its complex polygenic nature—a large multi-stage genome-wide association study identifies 128 independent associations in over 100 loci (83 of which are new); key findings include identification of genes involved in glutamergic neurotransmission and support for a link between the immune system and schizophrenia.

    • Stephan Ripke
    • Benjamin M. Neale
    • Michael C. O’Donovan
    Research
    Nature
    Volume: 511, P: 421-427

  • Schizophrenia trials are subject to multiple endpoint comparison problems, the risk of false-positives, patient non-compliance, high drop-out rates and missing data. Stroup and colleagues discuss current trial limitations and how these might be addressed by innovations in trial design and statistics.

    • T. Scott Stroup
    • Wayne M. Alves
    • Jeffrey A. Lieberman
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 133-146