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Showing 1–5 of 5 results
Advanced filters: Author: "Sebastian Glatt" Clear advanced filters

  • m6A is an mRNA modification that slows down translation elongation. Here, Jain et al. show that m6A delays decoding and increases tRNA drop-off from the ribosome by favoring alternative codon conformations that are rejected by the ribosome.

    • Sakshi Jain
    • Lukasz Koziej
    • Marina V. Rodnina
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stability and the activity of the complex during brain development.

    • Marija Kojic
    • Tomasz Gawda
    • Brandon J. Wainwright
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Elp3 is the catalytic subunit of the eukaryotic Elongator complex that catalyzes posttranscriptional tRNA modifications. Here the authors present the crystal structures of an acetyl-CoA analog bound bacterial Elp3 and a monomeric archaeal Elp3 and show that Elp3 functions as a tRNA modification enzyme in all domains of life.

    • Ting-Yu Lin
    • Nour El Hana Abbassi
    • Sebastian Glatt
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

    • Marija Kojic
    • Monika Gaik
    • Brandon J. Wainwright
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13