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Showing 1–2 of 2 results
Advanced filters: Author: "Shane Crotty" Clear advanced filters

  • The role of T cell help to B cells was discovered only a few years after the discovery of B cells. In this Timeline article, the author describes the key events that led to the identification of T follicular helper (TFH) cells as the main T helper cell type for B cells.

    • Shane Crotty
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 185-189

  • Follicular helper T cells (TFH cells) sequentially acquire the potential to secrete interleukin 21 (IL-21) and IL-4. The shift from secretion of IL-21 to that of IL-4 modifies the nature of the 'help' signals delivered by TFH cells to germinal center (GC) B cells.

    • Simon Bélanger
    • Shane Crotty
    News & Views
    Nature Immunology
    Volume: 17, P: 1135-1136