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Showing 1–4 of 4 results
Advanced filters: Author: "Shankar Balasubramanian" Clear advanced filters

  • DNA G-quadruplexes (G4s) are guanine-rich sequences that fold into four-stranded structures. Recent progress in the detection and mapping of genomic G4 structures has provided new insights into their functions in regulating transcription and genome stability, and has revealed their potential relevance for cancer therapy.

    • Robert Hänsel-Hertsch
    • Marco Di Antonio
    • Shankar Balasubramanian
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 279-284

  • G-quadruplexes are four-stranded DNA structures that appear to be over-represented in the promoter region of various genes, including oncogenes such asMYC and KRAS. This article discusses evidence indicating the possibility of therapeutically modulating the transcription of such genes through the targeting of G-quadruplexes with small molecules, and considers challenges and opportunities for the development of such molecules as anticancer drugs.

    • Shankar Balasubramanian
    • Laurence H. Hurley
    • Stephen Neidle
    Reviews
    Nature Reviews Drug Discovery
    Volume: 10, P: 261-275

  • During the cell cycle, the centromeres of chromosomes have important roles and face key challenges, such as mediating successful chromosome segregation during mitosis and faithfully propagating their chromatin state to daughter chromosomes during S phase. This Review describes cell cycle-related features of centromeres, focusing on the nature and dynamics of centromeric chromatin, how it is intricately regulated and the potential implications for disease when these processes are disrupted.

    • Sebastian Müller
    • Geneviève Almouzni
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 192-208

  • Various small molecules, including numerous anticancer agents, act by targeting DNA or protein components of chromatin. This Review describes how various complementary technologies use high-throughput sequencing to delineate drug responses, from identifying the genomic binding sites of drugs or their targets, to the ensuing changes to chromatin states and gene expression. These insights should facilitate the rational use of these therapies.

    • Raphaël Rodriguez
    • Kyle M. Miller
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 783-796