Patrick Tan, Bin Tean Teh, Steve Rozen and colleagues report recurrent somatic mutations in the cell-adhesion gene FAT4 and the chromatin-remodeling gene ARID1A in gastric adenocarcinomas. Their data suggest that FAT4 functions as a tumor suppressor by maintaining proper cell adhesion and preventing malignant cell migration.
- Zhi Jiang Zang
- Ioana Cutcutache
- Patrick Tan