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Showing 1–5 of 5 results
Advanced filters: Author: "Sherif Abou Elela" Clear advanced filters

  • Most yeast ribosomal protein genes are duplicated but the functional significance of this duplication remains unclear. This study identifies a natural program where changing the ratio of proteins produced from duplicated genes modifies translation in response to drugs regardless of ribosome number.

    • Mustafa Malik Ghulam
    • Mathieu Catala
    • Sherif Abou Elela
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Catala and Abou Elela show that the nuclear RNA degradation is executed in a promoter-specific manner, ensuring cell cycle-dependent gene expression. This study illustrates that local gene expression can be temporarily regulated without affecting overall transcription.

    • Mathieu Catala
    • Sherif Abou Elela
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-13

  • Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • Laurine Maignon
    • Sherif Abou Elela
    Research
    Nature
    Volume: 565, P: 612-617

  • Although splice isoforms have been observed to change in cancerous cells, the effect of these changes has not always been clear. Using antisense technology, cancer-associated isoforms have now been manipulated in cell lines. The results indicate that shifting splicing patterns of SYK can contribute to cell-cycle changes and anchorage-independent growth and that this change is also triggered by EGF signaling.

    • Panagiotis Prinos
    • Daniel Garneau
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 673-679

  • A large-scale screen for changes in alternative splice forms in cancer now reveals that almost half of the active alternative splicing events are shifted in breast and ovarian cancer tissues. In addition, many of these changes occur near consensus binding sequences for FOX2 binding sites. This correlates with changes in Fox2 expression or splicing in tissues assessed, and FOX2 depletion results in similar shifts in splice isoforms.

    • Julian P Venables
    • Roscoe Klinck
    • Sherif Abou Elela
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 670-676