Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: "Shingo Kajimura" Clear advanced filters

  • Cardiovascular risks of cold exposure and the subsequent activation of the β3-AR pathway limit the application of beige fat thermogenesis for the treatment of obesity. Here, the authors show that optogenetics light-activated Ca2+ cycling in adipocytes triggers a fat-specific “cold-mimetic” thermogenesis response protecting mice against diet-induced obesity.

    • Kazuki Tajima
    • Kenji Ikeda
    • Shingo Kajimura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Tajima and colleagues identify mitochondrial lipoylation as a post-transcriptional molecular signature of aged brown adipose tissue (BAT) in mice. Reduced mitochondrial lipoylation is tightly coupled with the age-associated decline in BAT function, whereas enhanced lipoylation restores BAT activity in aged mice.

    • Kazuki Tajima
    • Kenji Ikeda
    • Shingo Kajimura
    Research
    Nature Metabolism
    Volume: 1, P: 886-898

  • Adipose tissues have a central role in energy homeostasis, as they secrete adipokines and regulate energy storage and dissipation. Novel adipokines from white, brown and beige adipocytes have been identified in 2016. Identifying the specific receptors for each adipokine is pivotal for developing greater insights into the fat-derived signalling pathways that regulate energy homeostasis.

    • Shingo Kajimura
    News & Views
    Nature Reviews Endocrinology
    Volume: 13, P: 69-70

  • Inhibiting Notch signaling induces adipose browning, improves systemic glucose tolerance and insulin sensitivity, and suppresses weight gain in mice.

    • Thomas Gridley
    • Shingo Kajimura
    News & Views
    Nature Medicine
    Volume: 20, P: 811-812

  • Beige fat serves as a substantial metabolic sink that dissipates energy and has consequently attracted much attention as a target for improving metabolic health. A recent study has provided a new molecular target, the N-terminal acetyltransferase Naa10p, for harnessing beige-fat biogenesis and improving whole-body energy homeostasis1.

    • Qiang Wang
    • Shingo Kajimura
    News & Views
    Nature Structural & Molecular Biology
    Volume: 26, P: 849-851

  • Adipose tissue responds to a variety of hormonal and environmental cues with changes in size, cellular composition and metabolic activity. Here Kajimura and Chouchani review our current understanding of adipocyte metabolism in physiology and metabolic disease, and they discuss strategies to reprogram adipocyte fate and metabolism.

    • Edward T. Chouchani
    • Shingo Kajimura
    Reviews
    Nature Metabolism
    Volume: 1, P: 189-200

  • Embryonic, brown adipocytes, together with beige, brown-like adipocytes induced in white fat depots in response to various stimuli, constitute specialized heat-producing fat cells that contribute to organismal energy expenditure. Important insights have now been gained into the transcriptional and epigenetic regulation of biogenesis and thermogenesis of these cells, opening up new possibilities for the treatment of metabolic disorders.

    • Takeshi Inagaki
    • Juro Sakai
    • Shingo Kajimura
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 480-495