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Showing 1–9 of 9 results
Advanced filters: Author: "Shinya Yamanaka" Clear advanced filters

  • Six scientists in the field of stem cell research comment on our basic understanding of stem cells and other pluripotent cells, on their potential therapeutic use and on key challenges that remain.

    • Cédric Blanpain
    • George Q. Daley
    • Shinya Yamanaka
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 471-476

  • Four leading researchers contribute their personal opinions on recent progress and current challenges in induced pluripotent stem cell research. Their varied perspectives suggest that for clinical applications there is cause for optimism, tempered with caution, and they highlight exciting recent advances in reprogramming and differentiation.

    • Juan Carlos Izpisúa Belmonte
    • James Ellis
    • Shinya Yamanaka
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 878-883

    • Shinya Yamanaka
    Comments & Opinion
    Nature Medicine
    Volume: 15, P: 1145-1148

  • Researchers from across the field consider the new concepts that have emerged during the past decade of molecular cell biology research, and the key challenges still to be met.

    • Asifa Akhtar
    • Elaine Fuchs
    • Marino Zerial
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 669-674

  • Human pluripotent stem cells are being developed for therapeutic use in numerous conditions that affect different organs. In this Review, Kimbrel and Lanza discuss the history and science behind the approach and provide an overview of the products that are in clinical development or close to clinical development.

    • Erin A. Kimbrel
    • Robert Lanza
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 681-692

  • This year marks the tenth anniversary of the generation of induced pluripotent stem cells (iPSCs) by transcription factor-mediated somatic cell reprogramming. Takahashi and Yamanaka portray the path towards this ground-breaking discovery and discuss how, since then, research has focused on understanding the mechanisms underlying iPSC generation and on translating such advances to the clinic.

    • Kazutoshi Takahashi
    • Shinya Yamanaka
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 183-193

  • The ability to convert somatic cells to induced pluripotent stem cells has immense potential to further our understanding of development and disease mechanisms, and for cellular therapy. Before researchers can achieve these goals, they must expand current methodology to incorporate animal models and quantitative descriptions of the essential phenomena driving reprogramming.

    • Peter Karagiannis
    • Shinya Yamanaka
    Comments & Opinion
    Nature Methods
    Volume: 11, P: 1006-1008

  • Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. This article discusses progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, including the powerful combination of human iPSC technology with recent developments in gene editing.

    • Yanhong Shi
    • Haruhisa Inoue
    • Shinya Yamanaka
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 115-130

  • Stem cells reside in discrete microenvironments called niches, which regulate stem cell activity. The stem cell progeny appear to constitute an indispensable component of the niche in a wide range of stem cell systems. These unexpected niche inhabitants provide versatile feedback signals to their parent stem cells.

    • Ya-Chieh Hsu
    • Elaine Fuchs
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 103-114