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Showing 1–8 of 8 results
Advanced filters: Author: "Shuguang Yuan" Clear advanced filters

  • Pannexin 2 plays critical roles in many physiological processes but its mechanism remain unclear. Here, authors report the cryo-EM structure of human Panx2 in the open state and identify critical residues for its gating.

    • Hang Zhang
    • Shiyu Wang
    • Huawei Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Shuguang Yuan et al. report molecular modeling of the prototypical olfactory receptor Olfr73 and find that the binding pocket is much smaller but more flexible than that of typical G-protein-coupled receptors. They virtually screen 1.6 million compounds and predict 25 Olfr73 agonists, 17 of which are validated by cell-based assays.

    • Shuguang Yuan
    • Thamani Dahoun
    • Horst Vogel
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10

  • The Yersinia outer protein J (YopJ) family of effectors, which are present in many plant and animal pathogens are non-canonical acetyltransferases that are activated by the eukaryote-specific cofactor inositol hexaphosphate (InsP6). Here, the authors combine X-ray crystallography, biochemical and functional analyses to characterise the structure and activation mechanism of the YopJ family effector PopP2 from the plant pathogen Ralstonia solanacearum and observe that InsP6 binding induces major conformational changes in PopP2 with a helix-to-strand fold-switching in its catalytic core.

    • Yao Xia
    • Rongfeng Zou
    • Zhi-Min Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • The crystal structure of the A2A GPCR suggested that water molecules might form a continuous pathway that becomes disrupted during receptor activation. Here Yuan et al.instead show that a conserved layer of hydrophobic residues forms a gate that opens to form a continuous water channel upon receptor activation.

    • Shuguang Yuan
    • Slawomir Filipek
    • Horst Vogel
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Pentameric ligand-gated ion channels (pLGICs) are key players in neurotransmission and have been shown to be modulated by the lipid environment, however the underlying mechanism is not well understood. Here, the authors report structures of the pLGIC 5-HT3A serotonin receptor reconstituted into lipid bilayer discs and reveal lipid–protein interactions as well as asymmetric activation of the homopentameric receptor.

    • Yingyi Zhang
    • Patricia M. Dijkman
    • Mikhail Kudryashev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • GyrI-like proteins are small-molecule binding proteins that are widely distributed in prokaryotes and eukaryotes, with functions that are poorly characterized. Here, the authors identify GyrI-like proteins as cyclopropanoid cyclopropyl hydrolases that can confer resistance to cytotoxic cyclopropanoid compounds.

    • Hua Yuan
    • Jinru Zhang
    • Gong-Li Tang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8