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Showing 1–2 of 2 results
Advanced filters: Author: "Shuo Gu" Clear advanced filters
  • The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.

    • Acong Yang
    • Xavier Bofill-De Ros
    • Shuo Gu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • 3′ end of microRNAs binds to the PAZ domain of Argonaute (AGO) proteins. Here the authors show that terminal nucleotidyltransferases TUT4/7 and exonuclease DIS3L2 induce tailing and decay of 3’ end exposed-microRNAs in AGO PAZ mutant expressing- or cancer cells.

    • Acong Yang
    • Tie-Juan Shao
    • Shuo Gu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13