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Showing 1–6 of 6 results
Advanced filters: Author: "Silvia Corvera" Clear advanced filters

  • Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.

    • Emmanouela Tsagkaraki
    • Sarah M. Nicoloro
    • Michael P. Czech
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Thermogenic adipose tissue has been suggested as a potential target to treat metabolic diseases. Here, Tran et al. show that a long noncoding RNA, LINC00473, is induced during activation of thermogenic adipocytes and regulates energy metabolism through interorganelle communication.

    • Khanh-Van Tran
    • Erin L. Brown
    • Søren Nielsen
    Research
    Nature Metabolism
    Volume: 2, P: 397-412

  • Single-cell transcriptomic analysis of human multipotent progenitor cells reveals that upon adipogenic stimulation, Wnt signaling regulates the generation of functional multipotent mesenchymal progenitors, named structural Wnt-regulated adipose tissue resident cells, which maintain the progenitor pool.

    • Zinger Yang Loureiro
    • Shannon Joyce
    • Silvia Corvera
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1014-1028

  • Adipose tissue plays a critical role in systemic metabolism. This work describes how perturbations in the adipocyte progenitor cell repertoire during the perinatal period exert long-lasting metabolic effects in adulthood.

    • Silvia Corvera
    News & Views
    Nature Metabolism
    Volume: 4, P: 963-964