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Showing 1–2 of 2 results
Advanced filters: Author: "Somasekar Seshagiri" Clear advanced filters

  • Our understanding of inherited risk factors for colorectal cancer (CRC) is incomplete. A new study reports the identification of germline CRC risk variants that adversely affect the proofreading function of DNA polymerases encoded by POLE and POLD1.

    • Somasekar Seshagiri
    News & Views
    Nature Genetics
    Volume: 45, P: 121-122

  • Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Recent deep sequencing studies have shown that nearly 20% of human tumours harbour mutations in GPCRs. This Analysis article reviews these findings and the indications that G proteins, GPCRs and their signalling pathways represent novel therapeutic targets for cancer prevention and treatment.

    • Morgan O'Hayre
    • José Vázquez-Prado
    • J. Silvio Gutkind
    Research
    Nature Reviews Cancer
    Volume: 13, P: 412-424