Recent analyses have suggested that the intrinsic behaviour of tissue stem cells may be responsible for malignant transformation and cancer progression, raising questions regarding the influence of extrinsic factors on tumourigenesis; here, both data-driven and model-driven evidence show that such intrinsic risk factors contribute only marginally to cancer development, indicating that cancer risk is heavily influenced by extrinsic factors.
- Song Wu
- Scott Powers
- Yusuf A. Hannun
