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Showing 1–4 of 4 results
Advanced filters: Author: "Soumya Raychaudhuri" Clear advanced filters

  • Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.

    • Eli A. Stahl
    • Soumya Raychaudhuri
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 312-313

  • A rational approach to the management of rheumatoid arthritis (RA) begins with understanding the disease, development of which can be influenced by environmental, genetic and epigenetic factors. Genetic and epigenetic data in RA are revealing insights into pathogenesis and revitalizing the shared epitope hypothesis. These advances are discussed in this Review, alongside approaches to integrating the findings of genetic and functional studies.

    • Sebastien Viatte
    • Darren Plant
    • Soumya Raychaudhuri
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 141-153

  • Genome-wide approaches have advanced the study into mechanisms triggering autoimmunity. This Review illustrates how this has been achieved for twelve common autoimmune diseases, and discusses recent functional genomics approaches that have the potential to help define key immune molecular traits, cell types and cell states.

    • Maria Gutierrez-Arcelus
    • Stephen S. Rich
    • Soumya Raychaudhuri
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 160-174

  • RNA sequencing and mass cytometry are exciting new technologies that could revolutionize the analysis of immune cells. In this article, these developments and parallel advances in the analysis of big data are reviewed with the aim of advancing biomarker discovery.

    • Joerg Ermann
    • Deepak A. Rao
    • Soumya Raychaudhuri
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 541-551