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Showing 1–3 of 3 results
Advanced filters: Author: "Sreeram V Ramagopalan" Clear advanced filters

  • In multiple sclerosis, the ability of clinicians to provide a prognosis for a patient and the design and interpretation of clinical trials both rely heavily on prognostic factors identified from systematic natural history studies. Degenhardt and colleagues outline their criteria for well-designed natural history studies in multiple sclerosis and review the prognostic factors identified from such investigations for the various forms of the disease.

    • Alexandra Degenhardt
    • Sreeram V. Ramagopalan
    • George C. Ebers
    Reviews
    Nature Reviews Neurology
    Volume: 5, P: 672-682

  • Multiple sclerosis and type 1 diabetes mellitus are seemingly very different autoimmune diseases. However, this Review discusses recent studies in genetics, epidemiology and immunology that have uncovered many features common to both disorders. Overlaps between T1DM and MS might lead to similar strategies in preventing and treating these debilitating conditions.

    • Adam E. Handel
    • Lahiru Handunnetthi
    • Sreeram V. Ramagopalan
    Reviews
    Nature Reviews Endocrinology
    Volume: 5, P: 655-664

  • Epidemiological data indicate that genetic and environmental factors interact to determine an individual's risk of developing multiple sclerosis (MS). Handel et al. examine the key periods of life during which the environment might contribute to MS susceptibility, focusing on three putative MS risk factors: sun exposure (and its relationship with vitamin D levels), Epstein–Barr virus infection, and smoking.

    • Adam E. Handel
    • Gavin Giovannoni
    • Sreeram V. Ramagopalan
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 156-166