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Showing 1–16 of 16 results
Advanced filters: Author: "Stanley Falkow" Clear advanced filters

  • Thirteen years after the first bacterial genome was sequenced, Rino Rappuoli, Stanley Falkow and colleagues review what has changed in microbiology research as a consequence of genomics and address the implications of the genomic era for the future of microbiology.

    • Duccio Medini
    • Davide Serruto
    • Rino Rappuoli
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 419-430

  • The increase in allergic diseases that has occurred in developing countries in recent years has been attributed to a decrease in exposure to the microorganisms in the environment. Blaser and Falkow reflect that this increase, as well as the ongoing obesity epidemic and increased susceptibility to infectious disease, might instead be the result of changes in the human microbiota.

    • Martin J. Blaser
    • Stanley Falkow
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 7, P: 887-894

  • Helicobacter pyloriresides exclusively in the hostile environment of the stomach in approximately 50% of the human population and is a strong risk factor for cancer. Here, Salama, Hartung and Müller describe how this bacterium establishes persistent colonization through the interplay of virulence determinants and the subversion and manipulation of the host's immune response.

    • Nina R. Salama
    • Mara L. Hartung
    • Anne Müller
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 385-399

  • Similarities between the intracellular pathogenic strategies of the bacteriumYersinia pestis and the fungus Cryptococcus neoformansare used to illustrate the author's proposal that these pathogens acquired their intracellular survival strategies by a process of convergent evolution, possibly in response to interactions with other hosts in the environment, such as amoebae.

    • James B. Bliska
    • Arturo Casadevall
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 165-171

    • James B. Kaper
    • James P. Nataro
    • Harry L. T. Mobley
    Reviews
    Nature Reviews Microbiology
    Volume: 2, P: 123-140

  • This Review argues against the historical view of the granuloma as a host-protective structure and provides evidence that the innate immune mechanisms of tuberculous granulomas are involved in the expansion and dissemination of infection.

    • Lalita Ramakrishnan
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 352-366

  • EightEscherichia colipathovars have been well characterized to date. In this Review Matthew Croxen and Brett Finlay discuss recent advances in our understanding of the virulence of these pathovars that cause diseases affecting hundreds of millions of people worldwide annually.

    • Matthew A. Croxen
    • B. Brett Finlay
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 26-38

  • The use of antibiotics is making lasting alterations to the long-term relationship between a host and its microbiota. Willing, Russell and Finlay describe how these changes can result in the disruption of immune homeostasis and in increased susceptibility to disease.

    • Benjamin P. Willing
    • Shannon L. Russell
    • B. Brett Finlay
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 233-243

  • The causative agent of whooping cough,Bordetella pertussis, has recently re-emerged as a serious public health concern. Here, Cotter, Miller and colleagues discuss the pathogenesis of pertussis, the shortcomings of current vaccines and the future challenges that need to be addressed for the development of more effective therapeutic strategies.

    • Jeffrey A. Melvin
    • Erich V. Scheller
    • Peggy A. Cotter
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 274-288