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Showing 1–2 of 2 results
Advanced filters: Author: "Stefan Rose-John" Clear advanced filters

  • In this review, the authors discuss the role of IL-6 in the defence against infection, outlining insight gained from both preclinical and clinical studies, and examining the effects of IL-6-targeting therapies on immunocompetence and its clinical implications.

    • Stefan Rose-John
    • Kevin Winthrop
    • Leonard Calabrese
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 399-409

  • IL-6 has been linked to numerous inflammatory conditions (such as rheumatoid arthritis), and many IL-6-directed therapies are currently in development. The authors outline the basic biology of IL-6 and IL-6 signalling pathways before discussing the clinical implications of targeting IL-6 in the context of rheumatic diseases. Current and future indications for the use of IL-6-targeted therapies and safety of these agents are discussed.

    • Leonard H. Calabrese
    • Stefan Rose-John
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 720-727