The permeation of a drug across a biological membrane is one of the most important determinants of the pharmacokinetics of a drug. Here, the authors discuss the contribution of passive transport and carrier-mediated transport to the total permeation of a drug, focusing onin vitro and in vivoresults, as well as highlighting the implications for drug discovery.
- Kiyohiko Sugano
- Manfred Kansy
- Frank Senner
