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Showing 1–3 of 3 results
Advanced filters: Author: "Stephan Gruber" Clear advanced filters

  • Here, the authors biochemically demonstrate how the Smc5/6 SMC compartment holds a DNA loop by topologically entrapping DNA in two SMC subcompartments and the kleisin compartment. This mechanism requires the Nse5/6 loader to open the neck gate before DNA entrance.

    • Michael Taschner
    • Stephan Gruber
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 619-628

  • This study sheds light on the mechanism of transcription activation by which VirB, a virulence transcription activator in Shigella flexneri, the causative agent of the diarrheal disease shigellosis, uses the ribonucleotide CTP as a cofactor to load at specific DNA sites.

    • Hammam Antar
    • Stephan Gruber
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-10

  • Two studies using chromosome conformation capture (3C) analyses in the Gram-positive bacterium Bacillus subtilis have revealed a global pattern of chromosome organization that originates from loading sites of the Smc–ScpAB complex. Loading Smc–ScpAB at a single genomic location is sufficient to promote genome-wide folding of DNA into a well-defined structure.

    • Frank Bürmann
    • Stephan Gruber
    News & Views
    Nature Structural & Molecular Biology
    Volume: 22, P: 653-655