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Showing 1–4 of 4 results
Advanced filters: Author: "Stephan J. L. Bakker" Clear advanced filters

  • Albuminuria is rapidly gaining recognition as a marker of the presence and of the progression of chronic kidney disease (CKD). In a new study, Naresh et al. attempt to define cut-off values for percentage change in urinary albumin:creatinine ratio that reflect changes in CKD status rather than random biological variation.

    • Stephan J. L. Bakker
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 710-712

  • Blockade of the renin-angiotensin-aldosterone system (RAAS) is a standard treatment for patients with chronic kidney disease (CKD). Intensive strategies with single-agent or dual-agent RAAS blockade have been used to reduce proteinuria and blood pressure in these patients. This Review discusses strategies for improving the long-term outcomes of patients with CKD treated with RAAS blockade, focusing on the effects of combined low-dietary sodium intake and RAAS-blockade on the risk of renal and cardiovascular outcomes.

    • Hiddo J. Lambers Heerspink
    • Martin H. de Borst
    • Gerjan J. Navis
    Reviews
    Nature Reviews Nephrology
    Volume: 9, P: 112-121

  • Mineralocorticoid-receptor antagonists (MRAs) effectively reduce blood pressure and albuminuria in patients with chronic kidney disease who experience aldosterone breakthrough. Use of MRAs is limited, however, by the occurrence of hyperkalaemia, which frequently develops in patients with impaired kidney function, and/or diabetes. This Review discusses potential approaches to identify patients who are particularly prone to developing hyperkalaemia with MRA therapy and describes currently available and promising strategies to prevent and control hyperkalaemia in patients with CKD.

    • Sara S. Roscioni
    • Dick de Zeeuw
    • Hiddo J. Lambers Heerspink
    Reviews
    Nature Reviews Nephrology
    Volume: 8, P: 691-699

  • Regular physical activity is associated with reduced mortality in the general population and in patients with chronic kidney disease. Here, the authors discuss the importance of physical activity for patients with renal disease and patient-reported barriers and facilitators for physical activity.

    • Dorien M. Zelle
    • Gerald Klaassen
    • Gerjan Navis
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 152-168