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Showing 1–3 of 3 results
Advanced filters: Author: "Stephan R Targan" Clear advanced filters

    • Gil Y. Melmed
    • Stephan R. Targan
    • Peter Kirkpatrick
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 7, P: 641-642

  • IBD treatment has evolved towards biologic therapy, which seeks to target specific immune and biochemical abnormalities at the molecular and cellular level. Improved understanding of the pathogenesis of IBD has suggested future drug biologic targets, which are currently being investigated. This Review article discusses the potentials and pitfalls of biologic therapy for IBD as this field advances at a rapid pace.

    • Gil Y. Melmed
    • Stephan R. Targan
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 110-117

  • Ciclosporin and infliximab are used as rescue therapies for the treatment of severe steroid-refractory ulcerative colitis. Now, an open-label, head-to-head randomized controlled trial has demonstrated that these drugs are well-tolerated and have equivalent efficacy in inducing short-term clinical response, mucosal healing and decreasing colectomy rates at 3 months.

    • Manreet Kaur
    • Stephen R. Targan
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 10, P: 8-9