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Showing 1–5 of 5 results
Advanced filters: Author: "Stephen B Baylin" Clear advanced filters
  • Readout of information from the genome depends on intricate regulation of how DNA is packaged by proteins. The great endeavour to reveal how this packaging operates pan-genomically is now under way.

    • Stephen B. Baylin
    • Kornel E. Schuebel
    News & Views
    Nature
    Volume: 448, P: 548-549
  • Therapeutic resistance is a key roadblock to effective cancer treatment and can occur through various mechanisms. A recent study characterized a previously unknown, reversible mechanism of drug resistance mediated by an altered chromatin state, suggesting that cancer cell populations can use a dynamic strategy to ensure their survival when challenged by therapeutic intervention.

    • Stephen B Baylin
    News & Views
    Nature Medicine
    Volume: 17, P: 288-289
  • Chronic stress is increasingly implicated as a contributing factor in common diseases, including cancer, cardiovascular disease and diabetes. This Opinion article brings together evidence supporting the idea that stress can induce epigenetic changes that alter cell behaviour and thereby lead to disease.

    • Sarah E. Johnstone
    • Stephen B. Baylin
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 806-812
  • One of the biggest gaps in our knowledge about epigenomes is how their interplay with cellular signaling influences development, adult cellular differentiation and disease.

    • Helai P Mohammad
    • Stephen B Baylin
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 1033-1038