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Showing 1–8 of 8 results
Advanced filters: Author: "Stephen C. Harrison" Clear advanced filters

  • At least five recent papers have shown an unexpected antigenic relationship between Zika and dengue viruses, with potential implications for vaccines and therapeutics.

    • Stephen C Harrison
    News & Views
    Nature Immunology
    Volume: 17, P: 1010-1012

  • Transcription factors 'recognize' relatively short DNA consensus sequences; their full specificity must depend on a broader set of protein-protein and protein-DNA interactions. Joshi et al. show that, in addition to forming base pair–specific hydrogen bonds in the DNA major groove, certain Hox proteins detect DNA shape in the minor groove.

    • Stephen C Harrison
    News & Views
    Nature Structural & Molecular Biology
    Volume: 14, P: 1118-1119

  • Coat proteins of vesicles involved in intracellular membrane trafficking have closely related molecular architectures. The structure of COPI extends known similarities, and strengthens the case for a common evolutionary origin.

    • Stephen C. Harrison
    • Tomas Kirchhausen
    News & Views
    Nature
    Volume: 466, P: 1048-1049

  • Transport protein particle (TRAPP; also known as trafficking protein particle) complexes activate the GTPase Ypt1 or RAB1 to regulate membrane traffic in yeast and mammals, respectively. Two different TRAPP complexes tether coated vesicles during endoplasmic reticulum–Golgi and intra-Golgi traffic, respectively, and a third complex functions in autophagy. The TRAPP complexes thereby connect GTPase activation to unique membrane-tethering events.

    • Jemima Barrowman
    • Deepali Bhandari
    • Susan Ferro-Novick
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 759-763

  • To celebrate almost 50 years from the discovery of tubulin, six eminent researchers reflect on how the field of microtubule research has advanced over the past five decades, discuss impacts on clinical translation, and provide their thoughts on what key questions need to be addressed in the near future.

    • Gary Borisy
    • Rebecca Heald
    • Eva Nogales
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 322-328

  • The spindle-assembly checkpoint is a safety device that monitors the attachment of spindle microtubules to kinetochores and ensures the fidelity of chromosome segregation in mitosis. Molecular studies are finally starting to reveal the mechanisms of checkpoint activation and inactivation.

    • Andrea Musacchio
    • Edward D. Salmon
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 379-393

  • Bacteria use a range of regulatory strategies to control replication initiation, many of which are tightly connected to the activities of the bacterial initiator DnaA. Here, Melissa Mott and James Berger review our current understanding of the mechanisms and regulation of bacterial DNA replication initiation, with a particular emphasis on DnaA.

    • Melissa L. Mott
    • James M. Berger
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 343-354