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Showing 1–3 of 3 results
Advanced filters: Author: "Stephen D. Nimer" Clear advanced filters

  • A new study provides a rationale for the use of poly (ADP-ribose) polymerase (PARP) inhibitors to trigger irreparable DNA damage as a therapeutic approach in acute myeloid leukemia (AML). It also provides support for combining PARP inhibitors with agents that reduce HOXA9 protein levels.

    • Lan Wang
    • Pierre-Jacques Hamard
    • Stephen D Nimer
    News & Views
    Nature Medicine
    Volume: 21, P: 1393-1394

  • Innate immune signals and p53 contribute to the 5q– myelodysplastic syndrome, an acquired bone marrow failure disorder (pages 49–58 and 59–66).

    • Yan Liu
    • Takashi Asai
    • Stephen D Nimer
    News & Views
    Nature Medicine
    Volume: 16, P: 30-32

  • The interplay between cellular signalling pathways and chromatin modifications adds another layer of complexity to the already complex regulation of the epigenome. This Review discusses how signalling connections to epigenetics contribute to the molecular pathogenesis of neoplasia.

    • Fan Liu
    • Lan Wang
    • Stephen D. Nimer
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 359-372