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Showing 1–9 of 9 results
Advanced filters: Author: "Steven E. Hyman" Clear advanced filters

  • The more we study the genetics of schizophrenia, says Steven E. Hyman, the more daunting — and exciting — are the challenges we see ahead.

    • Steven E. Hyman
    Comments & Opinion
    Nature
    Volume: 508, P: S20

  • The classification of psychiatric disorders in the DSM has been influential in neuroscience research but has also been subject to criticism. In this Viewpoint, six leaders in the field discuss whether the latest version, DSM-5, as well as the dimensional approach provided by the RDoC, will move psychiatry research forward.

    • B. J. Casey
    • Nick Craddock
    • Kerry J. Ressler
    Reviews
    Nature Reviews Neuroscience
    Volume: 14, P: 810-814

  • Many neuroscientists are motivated by the hope that their research will ultimately benefit people with neurological and mental disorders. Steven Hyman asks whether neuroscience has progressed to the point that the diagnostic manuals for mental disorders can usefully incorporate its findings.

    • Steven E. Hyman
    Reviews
    Nature Reviews Neuroscience
    Volume: 8, P: 725-732

  • A report in this issue suggests that inhibiting histone deacetylase 2 (HDAC2) could be therapeutic in schizophrenia. Targeting chromatin remodeling in adults to treat a chronic brain disorder is not, however, likely to be easy.

    • Steven E Hyman
    News & Views
    Nature Neuroscience
    Volume: 15, P: 1180-1181

  • Roughly 2% of humans suffer from obsessive compulsive disorder, but a lack of animal models has impeded research into this condition. Could a genetically engineered mouse model provide an exciting lead?

    • Steven E. Hyman
    News & Views
    Nature
    Volume: 448, P: 871-872

  • An obsession with producing and validating models (face, construct, predictive validity) has led many of us down a deep rabbit hole, thinking about models instead of mechanisms. Advances in the human genetics and neurobiology of brain disorders create exciting new opportunities, but only if we can get back to basics.

    • Steven E Hyman
    Correspondence
    Nature Neuroscience
    Volume: 19, P: 1383-1384

  • A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action and investment.

    • Pamela Y. Collins
    • Vikram Patel
    • Mark Walport
    Comments & Opinion
    Nature
    Volume: 475, P: 27-30