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  • High-throughput measurements across several regulatory levels provide a comprehensive view of ES-cell differentiation.

    • Jonghwan Kim
    • Stuart H Orkin
    News & Views
    Nature Biotechnology
    Volume: 28, P: 146-147

  • DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

    • Jennifer J Trowbridge
    • Stuart H Orkin
    News & Views
    Nature Genetics
    Volume: 44, P: 13-14

  • For practical and ethical reasons, researchers are on the lookout for ways to reprogramme one mature cell type into another. In one case, this might be as easy as switching off a single gene.

    • Huafeng Xie
    • Stuart H. Orkin
    News & Views
    Nature
    Volume: 449, P: 410-411