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Showing 1–6 of 6 results
Advanced filters: Author: "Susan Thomas" Clear advanced filters

  • Lymphatic vessels within and near to tumours facilitate nanoparticle transport out of tumours, with ramifications in the design and implementation of next-generation clinical cancer nanomedicines.

    • Meghan J. O’Melia
    • Susan N. Thomas
    News & Views
    Nature Materials
    Volume: 22, P: 1287-1288

  • Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic delivery of a nitric oxide donor and an anti-CTLA4 antibody, showing anti-tumor immune responses in preclinical cancer models.

    • Jihoon Kim
    • David M. Francis
    • Susan N. Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Nanoparticles that access lymphatic vessels and are functionalized with degradable linkers, whose half-lives can be programmed, enable the controlled release of therapeutic cargo in different regions of the lymph nodes, allowing the targeting of otherwise difficult-to-reach lymphocyte subpopulations.

    • Alex Schudel
    • Asheley Poole Chapman
    • Susan Napier Thomas
    Research
    Nature Nanotechnology
    Volume: 15, P: 491-499

  • Multistep mechanosensing of lymphocyte infiltration and proliferation by the remodeling stroma and matrix underlies the immensely rapid and massive tissue expansion by lymph nodes in response to immune challenge.

    • Yunus Alapan
    • Susan N. Thomas
    News & Views
    Nature Immunology
    Volume: 23, P: 1139-1141

  • Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.

    • Alex Schudel
    • David M. Francis
    • Susan N. Thomas
    Reviews
    Nature Reviews Materials
    Volume: 4, P: 415-428