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Showing 1–13 of 13 results
Advanced filters: Author: "Susumu Tonegawa" Clear advanced filters

  • Long-term memory formation is associated with bidirectional changes in synaptic strength that require enhanced protein synthesis. Govindarajan, Kelleher and Tonegawa describe a model by which translation-dependent plasticity at synapses that are clustered in a dendritic branch facilitates the formation of long-term memory engrams.

    • Arvind Govindarajan
    • Raymond J. Kelleher
    • Susumu Tonegawa
    Reviews
    Nature Reviews Neuroscience
    Volume: 7, P: 575-583

  • Two new protein tools translate neuronal activity into gene expression during a light-defined time window.

    • Dheeraj S Roy
    • Teruhiro Okuyama
    • Susumu Tonegawa
    News & Views
    Nature Biotechnology
    Volume: 35, P: 827-828

  • Each tissue in our body contains a unique microenvironment that can differentially shape immune reactivity. In this Review article, Shiet al. describe how organ-specific factors influence natural killer cell homing and phenotype, and discuss the local molecular and cellular interactions that determine the protective or pathogenic functions of natural killer cells in the different tissues.

    • Fu-Dong Shi
    • Hans-Gustaf Ljunggren
    • Luc Van Kaer
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 658-671

  • An appreciation of the crosstalk between cells of the innate and the adaptive immune system is increasingly important for understanding both health and disease. As highlighted here, reciprocal regulation between natural killer cells and autoreactive T cells can influence all stages of autoimmune disease.

    • Fu-Dong Shi
    • Luc Van Kaer
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 751-760

    • Dale I. Godfrey
    • H. Robson MacDonald
    • Luc Van Kaer
    Reviews
    Nature Reviews Immunology
    Volume: 4, P: 231-237

  • Memories are thought to be represented in the brain by the 'memory trace' — altered levels of activity in specific neurons and synapses in a neural network. In this Review, Silva and colleagues discuss emerging evidence that the neurons and synapses involved in encoding a particular memory are not random but are specifically 'allocated' based on complex molecular signatures that are determined by the recent activity history of the neuron.

    • Thomas Rogerson
    • Denise J. Cai
    • Alcino J. Silva
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 157-169

  • What determines whether a tissue or organism can regenerate? What are the cellular sources of regeneration? How are regenerative signals initiated and targeted, and what controls proliferation and patterning during regeneration? Studies in a range of model systems are addressing these key questions.

    • Kenneth D. Poss
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 710-722

  • The localization of mRNAs coupled with precise translational control is an important mechanism that is used by cells to establish functionally distinct compartments. Translation of localizing mRNAs is repressed by mechanisms that target translation initiation, and is derepressed following arrival at the final destination.

    • Florence Besse
    • Anne Ephrussi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 971-980

  • This Review critically assesses six signatory roles of the often overlooked γδ T cells that may collectively distinguish these cells from αβ T cells, and thereby define their unique contributions to lymphocyte biology.

    • Pierre Vantourout
    • Adrian Hayday
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 88-100

  • A number of transgenic mouse strains show enhanced learning and memory. Silva and Lee analyse the molecular pathways affected in these mice, highlighting the central role of the NMDA receptor, the transcription factor CREB and long-term potentiation.

    • Yong-Seok Lee
    • Alcino J. Silva
    Reviews
    Nature Reviews Neuroscience
    Volume: 10, P: 126-140