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Showing 1–2 of 2 results
Advanced filters: Author: "Suzanne M. Leal" Clear advanced filters

  • Seven leading geneticists express their views about where the unidentified components of the heritability for complex human diseases might lie and how this could affect the underlying genetic architecture, as well as offering suggestions of how genomic research could be targeted to address this key issue.

    • Evan E. Eichler
    • Jonathan Flint
    • Joseph H. Nadeau
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 446-450

  • Before genome-wide association studies, linkage analysis was the primary approach used for genetic mapping of complex traits in humans. Now, with the widespread application of whole-genome sequencing (WGS), linkage analysis based on WGS data is emerging as a useful tool for the identification of susceptibility genes for human disease. This Review reiterates the main principles of linkage analysis and provides guidelines for performing linkage analysis on WGS data.

    • Jurg Ott
    • Jing Wang
    • Suzanne M. Leal
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 275-284