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Showing 1–6 of 6 results
Advanced filters: Author: "Sven Panke" Clear advanced filters

  • Building multi-component enzymatic processes in one pot is challenged by the inherent complexity of each biochemical system. Here, the authors use online mass spectroscopy and engineering systems theory to achieve forward design of a ten-membered reaction cascade.

    • Christoph Hold
    • Sonja Billerbeck
    • Sven Panke
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • Combinatorial shuffling of peptide sequence modules, post-translational modification and screening with a high-throughput growth inhibition assay results in the identification of lanthipeptide variants with altered antibacterial activities.

    • Steven Schmitt
    • Manuel Montalbán-López
    • Sven Panke
    Research
    Nature Chemical Biology
    Volume: 15, P: 437-443

  • Metabolic engineering often involves the addition of enzymes, redirection of metabolic flux or elimination of undesirable endpoints and thus requires laborious optimization of numerous parameters. A new method to derive 'blueprints' from real-time measurements of metabolic networks significantly accelerates this process as demonstrated with the production of dihydroxyacetone phosphate.

    • Matthias Bujara
    • Michael Schümperli
    • Sven Panke
    Research
    Nature Chemical Biology
    Volume: 7, P: 271-277

  • Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.

    • Markus Jeschek
    • Daniel Gerngross
    • Sven Panke
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • An artificial metalloenzyme is compartmentalized and evolved in vivo for olefin metathesis—an archetypal organometallic reaction without equivalent in nature; the evolved metathase reveals broad substrate scope and compares favourably with commercial catalysts.

    • Markus Jeschek
    • Raphael Reuter
    • Thomas R. Ward
    Research
    Nature
    Volume: 537, P: 661-665