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Showing 1–21 of 21 results
Advanced filters: Author: "Sylvain Moineau" Clear advanced filters

  • The bacterial ‘adaptive’ immune system known as CRISPR-Cas destroys foreign DNA molecules, such as viral genomes, to which the cells have previously been exposed. Here, Hynes et al.show that this gain of immunity is favoured by exposure to defective viruses, a result reminiscent of vaccination.

    • Alexander P. Hynes
    • Manuela Villion
    • Sylvain Moineau
    Research
    Nature Communications
    Volume: 5, P: 1-6

  • Recent studies have revealed that bacteriophages have a remarkable capacity to defend against the antiviral systems of their bacterial hosts. Here, Moineau and colleagues discuss the diverse mechanisms that phages use to evade adsorption inhibition, restriction–modification systems, CRISPR–Cas systems and abortive infection.

    • Julie E. Samson
    • Alfonso H. Magadán
    • Sylvain Moineau
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 675-687

  • To prevent infection by phages, bacteria have evolved a diverse range of resistance mechanisms. Moineau and colleagues highlight recent work to characterize these resistance strategies and discuss how phages have adapted to overcome many of these mechanisms, triggering an evolutionary arms race with their hosts.

    • Simon J. Labrie
    • Julie E. Samson
    • Sylvain Moineau
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 317-327

  • Phages can use ACR proteins that inhibit the adaptive immunity activities of bacterial CRISPR-Cas systems. Here, Philippe et al. show that these systems can block ACR-containing phages by targeting the acr gene, and this can select for phage mutants carrying a deletion within acr that does not block DNA cleavage (interference) but prevents the addition of new immunity (spacer acquisition).

    • Cécile Philippe
    • Carlee Morency
    • Sylvain Moineau
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • The full list of weapons used by bacteria against viruses is not known. A computational approach has uncovered nine previously unidentified antiviral systems, encoded by genes near known defence genes in bacterial genomes.

    • Sébastien Levesque
    • Sylvain Moineau
    News & Views
    Nature
    Volume: 556, P: 318-319

  • The discovery that some viruses use a defence mechanism known as a CRISPR/Cas system beautifully illustrates the evolutionary tit-for-tat between viruses and the bacteria they infect. See Letter p.489

    • Manuela Villion
    • Sylvain Moineau
    News & Views
    Nature
    Volume: 494, P: 433-434

  • CRISPR-Cas and restriction–modification are two distinct bacterial defence systems that protect against phage infection. Dupuis et al. demonstrate that Streptococcus thermophilusemploys both systems simultaneously to cleave invading DNA, thereby providing enhanced phage resistance.

    • Marie-Ève Dupuis
    • Manuela Villion
    • Sylvain Moineau
    Research
    Nature Communications
    Volume: 4, P: 1-7

  • CRISPR–Cas is an adaptive immune system found in Bacteria and Archaea that confers sequence-specific protection against invasion by foreign nucleic acids. CRISPR–Cas is also a powerful tool for microbiology education and has been an inspiring model for our students for the past three years.

    • Luc Trudel
    • Michel Frenette
    • Sylvain Moineau
    Comments & Opinion
    Nature Microbiology
    Volume: 2, P: 1-2

  • CRISPR/Cas is a microbial immune system that is known to protect bacteria from virus infection. These authors show that the Streptococcus thermophilus CRISPR/Cas system can prevent both plasmid carriage and phage infection through cleavage of invading double-stranded DNA.

    • Josiane E. Garneau
    • Marie-Ève Dupuis
    • Sylvain Moineau
    Research
    Nature
    Volume: 468, P: 67-71

  • Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.

    • Alexander P. Hynes
    • Geneviève M. Rousseau
    • Sylvain Moineau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems are immunity systems that are present in many bacteria and archaea. Here, Koonin and colleagues present a new classification of these systems and introduce a new nomenclature of the genes in the CRISPR–casloci that better reflects the relationships between the proteins.

    • Kira S. Makarova
    • Daniel H. Haft
    • Eugene V. Koonin
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 467-477

  • Phages are tremendously abundant and are found in every environment where bacteria exist. In this Review, Dion, Oechslin and Moineau explore the diversity of phages at the structural, genomic and community levels as well as their complex evolutionary relationships.

    • Moïra B. Dion
    • Frank Oechslin
    • Sylvain Moineau
    Reviews
    Nature Reviews Microbiology
    Volume: 18, P: 125-138

  • A recent paper gives the details on how specific small RNAs can program a protein to cleave an undesired piece of DNA and to provide immunity to a microbial cell.

    • Manuela Villion
    • Sylvain Moineau
    Research Highlights
    Cell Research
    Volume: 23, P: 15-17