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Showing 1–15 of 15 results
Advanced filters: Author: "T Kouzarides" Clear advanced filters

  • Treatment with a specific inhibitor of the N6-methyladenosine methyltransferase METTL3 leads to reduced growth of cancer cells, indicating the potential of approaches targeting RNA-modifying enzymes for anticancer therapy.

    • Eliza Yankova
    • Wesley Blackaby
    • Tony Kouzarides
    Research
    Nature
    Volume: 593, P: 597-601

  • Methylation at particular residues on histone tails has been associated with various functions and, in the case of dimethylated histone H3 arginine 2 (H3R2), cross-talk with methylation of a nearby lysine has been shown to be linked to transcriptional repression. Budding yeast monomethylated H3R2 is now shown to be associated with active loci and involved in activation of meiotic genes upon induction of sporulation.

    • Antonis Kirmizis
    • Helena Santos-Rosa
    • Tony Kouzarides
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 449-451

  • Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.

    • Adrien Leger
    • Paulo P. Amaral
    • Tony Kouzarides
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Nucleosome stability can influence gene expression and is regulated by nucleosome-positioning sequences, histone chaperones, remodeling complexes, post-translational modifications and histone variants. Now, histone H3 tail clipping has been added to the list. Kouzarides and co-workers have identified a serine endopeptidase in yeast that cleaves H3 after Ala21 and shows a preference for H3 tails with repressive modifications. In vivo, this occurs at the promoters of induced genes and precedes histone eviction when genes become fully active.

    • Helena Santos-Rosa
    • Antonis Kirmizis
    • Tony Kouzarides
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 17-22

  • SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.

    • Konstantinos Tzelepis
    • Etienne De Braekeleer
    • George S. Vassiliou
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Tzelepis, Rausch and Kouzarides review the action of RNA modifications in the context of chromatin and discuss the emerging potential of RNA-modifying enzymes as new drug targets.

    • Konstantinos Tzelepis
    • Oliver Rausch
    • Tony Kouzarides
    Reviews
    Nature Structural & Molecular Biology
    Volume: 26, P: 858-862

  • Methylation of histone H3 on residue Lys4 (H3K4) contributes to transcription activation. Now it is shown that in budding yeast, an adjacent modification, methylated Arg2, can inhibit H3K4 methylation by preventing the binding of a methyl transferase complex.

    • Antonis Kirmizis
    • Helena Santos-Rosa
    • Tony Kouzarides
    Research
    Nature
    Volume: 449, P: 928-932

  • The activation of Janus kinase 2 (JAK2), a non-receptor tyrosine kinase that regulates several cellular processes by inducing cytoplasmic signalling cascades, is a frequent event in haematological malignancies. Here, human JAK2 is shown to be present in the nucleus of haematopoietic cells, where it directly phosphorylates Tyr 41 on histone H3, thus preventing the binding of heterochromatin protein Iα.

    • Mark A. Dawson
    • Andrew J. Bannister
    • Tony Kouzarides
    Research
    Nature
    Volume: 461, P: 819-822

  • This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

    • Maria A. Christophorou
    • Gonçalo Castelo-Branco
    • Tony Kouzarides
    Research
    Nature
    Volume: 507, P: 104-108

  • Recent data suggest that histone modifications have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone–histone and histone–DNA interactions, as well as the binding of histones to chaperones.

    • Peter Tessarz
    • Tony Kouzarides
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 703-708