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Showing 1–17 of 17 results
Advanced filters: Author: "T Martin" Clear advanced filters

  • It has long been known that mutations in the body of the tRNA can affect translational fidelity, but how? The crystal structures of the 70S ribosome complexed to EF-Tu and wild type and mutant aminoacyl-tRNAs bound to cognate and near-cognate codons now show that the mutants cause miscoding by different means. The so-called Hirsh suppressor (G24A) promotes an additional internal interaction while the A9C mutant enhances tRNA flexibility, but they both decrease the energetic penalty for tRNA distortion.

    • T Martin Schmeing
    • Rebecca M Voorhees
    • V Ramakrishnan
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 432-436

  • Primary plastids descend from an endosymbiosis involving cyanobacteria, an ancient eukaryotic host and, possibly, a chlamydial pathogen. Here, Domman and colleagues use sophisticated phylogenetic methods to show that Chlamydiaedid not play a role in establishing the primary plastid endosymbiosis.

    • Daryl Domman
    • Matthias Horn
    • Tom A. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Microsporidia contain a tiny mitochondrial remnant called a mitosome, but the function of this organelle is unknown. Microsporidian genomes encode several components of the mitochondrial iron–sulphur-cluster machinery. This paper describes the cloning, characterization and subcellular localization of several Fe–S-cluster components for two microsporidia. Although some components localize to the mitosome, others are cytosolic, raising questions about how their function is coordinated.

    • Alina V. Goldberg
    • Sabine Molik
    • T. Martin Embley
    Research
    Nature
    Volume: 452, P: 624-628

  • The parasite Encephalitozoon cuniculi contains mitosomes instead of functional mitochondria. Although mitochondrial carrier proteins are known to be responsible for ATP transport from the mitochondria to the cytosol, Hirt et al. now show this process to be reversed in E. cuniculi, where ATP appears to be transported from the cytosol to the organelle.

    • Anastasios D. Tsaousis
    • Edmund R. S. Kunji
    • T. Martin Embley
    Research
    Nature
    Volume: 453, P: 553-556

  • The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is likely linked to its role in cytosolic and nuclear iron–sulfur protein maturation.

    • Sven-A. Freibert
    • Alina V. Goldberg
    • Roland Lill
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The arrest peptides that function with the macrolide antibiotic erythromycin stall translating ribosomes in the presence of the antibiotic, leading to remodeling of the downstream mRNA and enhancement of the translation of resistance genes. Current work suggests that small changes in the nascent peptide dictate the ability of ribosomes to respond to this and other small molecules.

    • Diego A Alonzo
    • T Martin Schmeing
    News & Views
    Nature Chemical Biology
    Volume: 12, P: 127-128

  • A new archaeal phylum represents the closest known relatives of eukaryotes, the group encompassing all organisms that have nucleated cells. The discovery holds promise for a better understanding of eukaryotic origins. See Article p.173

    • T. Martin Embley
    • Tom A. Williams
    News & Views
    Nature
    Volume: 521, P: 169-170

  • It is now well established that mitochondria - organelles that consume oxygen and produce ATP - arose from an endosymbiotic bacterium that colonized eukaryotic cells. This has led scientists to wonder whether hydrogenosomes, which generate hydrogen as a by-product of ATP synthesis, might have arisen in the same way. Support for this idea now comes from the identification of a hydrogenosome that contains its own genome.

    • T. Martin Embley
    • William Martin
    News & Views
    Nature
    Volume: 396, P: 517-519

  • Biologists use phylogenetic trees to depict the history of life. But according to a new and roundabout view, such trees are not the best way to summarize life's deepest evolutionary relationships.

    • William Martin
    • T. Martin Embley
    News & Views
    Nature
    Volume: 431, P: 134-137

  • Accumulating evidence that the eukaryotic nuclear lineage originated from within the Archaea provides support for a tree containing only two primary domains of life—the Achaea and Bacteria—over the currently accepted ‘three-domains tree’.

    • Tom A. Williams
    • Peter G. Foster
    • T. Martin Embley
    Reviews
    Nature
    Volume: 504, P: 231-236