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Showing 1–2 of 2 results
Advanced filters: Author: "TONY KOUZARIDES" Clear advanced filters

  • Recent data suggest that histone modifications have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone–histone and histone–DNA interactions, as well as the binding of histones to chaperones.

    • Peter Tessarz
    • Tony Kouzarides
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 703-708

  • After synthesis, all RNA molecules are subject to covalent modifications. This Review presents the evidence that RNA modification pathways are misregulated in cancer and suggests that they may be ideal targets for cancer therapy.

    • Isaia Barbieri
    • Tony Kouzarides
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 303-322